Expanding the Genetic Code (EGC)

Workshop on the 4th August 2017, CeBiTec Bielefeld

On the occasion of the participation of the team Bielefeld-CeBiTec in the international iGEM competition, this year we are hosting a workshop at the Center for Biotechnology (CeBiTec). The workshop, to which scientists from the field of synthetic biology are invited, is intended to provide a forum for presentations and discussions of current research related to non-canonical amino acids (ncAAs) and unnatural base pairs (UBPs).

With their broad chemical and functional diversity ncAAs provide a variety of promising applications including protein labeling, photocaging, structure analysis and specific protein interactions. Therefore, the development of a new iGEM toolkit for the translational incorporation of ncAAs in E. coli would be a great contribution to the iGEM community. The site-specific incorporation of ncAAs requires the directed evolution of tRNA and aminoacyl tRNA synthetase pairs, which in turn mediate the introduction of a ncAA for a certain codon. A goal is to explore the application of UBPs as an expansion of the genetic code. This approach promises an optimal orthogonality to the autologous translation apparatus and a high flexibility concerning the incorporation of multiple ncAAs.

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We are pleased to announce that the following program:

14:00 Welcome

14:15 Team:Bielefeld-CeBiTec 2017 project introduction: 'Expanding the Genetic Code' (Bielefeld-CeBiTec Project)

15:15 Dr. Nediljko Budisa, Berlin, 'Potentials of noncanonical amino acids in synthetic biology'

16:30 Iker Valle Aramburu, Heidelberg, on the plasticity of FG-Nucleoporins and NTR interactions

17:30 Concluding Remarks

18:00 Poster Session

19:00 Internal discussion of the iGEM team with the invited speakers

There will be short breaks between the talks. Drinks and snacks will be provided. We are hoping for a large attendance and are looking forward to your thoughts and suggestions.